Table 3.
Performance parameters obtained during accuracy assessment of the different analytical methods developed to perform dexamethasone, hydrochlorothiazide, phenytoin, or spironolactone assay.
| Colonne1 | Spironolactone | Dexamethasone | Hydrochlorothiazide | Phenytoin |
|---|---|---|---|---|
| Target concentration (mg/mL) | 5.0 | 5.0 | 2.0 | 5.0 |
| Mean concentration (mg/mL) | Repeatability | |||
| 4.9 | 5.0 | 2.0 | 5.0 | |
| RSD (%) | 4.4 | 1.3 | 3.6 | 4.0 |
| CI 95% (%) | [4.2 ; 4.7] | [1.3 ; 1.4] | [3.5 ; 3.6] | [1.9 ; 6.0] |
| Mean concentration (mg/mL) | Intermediate precision | |||
| 5.0 | 4.9 | 2.0 | 5.0 | |
| RSD (%) | 3.0 | 3.2 | 4.0 | 3.1 |
| CI 95% (%) | [2.9 ; 3.1] | [3.1 ; 3.3] | [3.9 ; 4.0] | [2.3 ; 3.8] |
| Recovery rate (%) | Trueness | |||
| 100.5 | 98.8 | 99.8 | 99.7 | |
| 95% CI (%) | [99.0 ; 102.0] | [97.3 ; 100.4] | [97.8 ; 101.7] | [98.2 ; 101.2] |
CI: confidence interval; RSD: relative standard deviation.