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. 2019 Apr 18;11(4):188. doi: 10.3390/pharmaceutics11040188

Figure 4.

Figure 4

M2e5x VLP supplemented influenza split vaccination induces enhanced IgG antibody responses to different subtype viral antigens. BALB/c mice (N = 6) were immunized with A/Cal split vaccine (Split), M2e5x VLP alone (M2e5x), or split vaccine supplemented with M2e5x VLPs (S-M2e5x). Sera collected 3 weeks after boost (B) vaccination were used to determine IgG antibody responses to different subtype viral antigens. (A) IgG antibody responses to influenza A/Phil (A/Philippines/2/82, H3N2). (B) IgG antibody responses to influenza rgH5N1 (A/PR8 reassortant containing HA, NA, and M from A/Mandarin duck/PSC24-24/2010). One-way ANOVA and Tukey’s post-multiple comparison test were performed. *; p < 0.05 between the split and S-M2e5x groups.