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Patterns of altered neural activation and connectivity during emotion regulation in adolescents with depression. Overall, studies to date have demonstrated altered activation and connectivity in the amygdala and across regions of prefrontal cortex. The directionality of effects (greater or lesser in depressed compared to non-depressed participants), and the specific set of regions involved however varies across studies. (PFC: prefrontal cortex, dm/dlPFC: dorsomedial/dorsolateral PFC)
