Table 2.
Univariate and multivariate analyses of PLCL1 mRNA level and patient survival
| Variable | Univariate analysis | Multivariate analysisc) | ||||
|---|---|---|---|---|---|---|
| HRa) | 95% CIb) | P | HR | 95% CI | P | |
| Overall survival (n = 517) | ||||||
| Age (years) | ||||||
| ≤60 (n = 257) | 1.766 | 1.297–2.404 | 0.000 | 1.717 | 1 .258–2.343 | 0.001 |
| >60 (n = 260) | ||||||
| Gender | ||||||
| Female (n = 181) | 0.965 | 0.707–1.318 | 0.825 | |||
| Male (n = 336) | ||||||
| T stage | ||||||
| T1 or T2 (n = 332) | 3.043 | 2.245–4.124 | 0.000 | 1.660 | 1.173–2.350 | 0.004 |
| T3 or T4 (n = 185) | ||||||
| N stage | ||||||
| N0 or NX (n = 503) | 3.554 | 1.871–6.748 | 0.000 | |||
| N1 (n = 14) | ||||||
| M stage | ||||||
| M0 or MX (n = 441) | 4.369 | 3.197–5.971 | 0.000 | 2.940 | 2.070–4.173 | 0.000 |
| M1 (n = 76) | ||||||
| G grade | ||||||
| G1 or G2 (n = 239) | 2.605 | 1.853–3.661 | 0.000 | 1.606 | 1.118–2.307 | 0.010 |
| G3 or G4 (n = 278) | ||||||
| PLCL1 | ||||||
| Low (n = 258) | 0.526 | 0.385–0.718 | 0.000 | 0.615 | 0. 449–0.844 | 0.003 |
| High (n = 259) | ||||||
a)
Multivariate models were adjusted for T, N, M classification, age, and gender
b)
Hazard ratio, estimated from Cox proportional hazard regression model
c)
Confidence interval of the estimated HR.