Table 3.
Univariate and multivariate analyses of PLCL1 mRNA level and patient survival
| Variable | Univariate analysis | Multivariate analysisa) | ||||
|---|---|---|---|---|---|---|
| HRb) | 95% CIc) | P | HR | 95% CI | P | |
| Disease–free survival (n = 421) | ||||||
| Age (years) | ||||||
| ≤60 (n = 228) | 1.363 | 0.957–1.941 | 0.086 | |||
| >60 (n = 193) | ||||||
| Gender | ||||||
| Female (n = 142) | 1.421 | 0.956–2.111 | 0.082 | |||
| Male (n = 279) | ||||||
| T stage | ||||||
| T1 or T2 (n = 282) | 4.503 | 3.117–6.504 | 0.000 | 2.127 | 1.401–3.228 | 0.000 |
| T3 or T4 (n = 139) | ||||||
| N stage | ||||||
| N0 or NX (n = 409) | 5.915 | 2.969–11.781 | 0.000 | 2.768 | 1.358–5.639 | 0.005 |
| N1 (n = 12) | ||||||
| M stage | ||||||
| M0 or MX (n = 370) | 8.494 | 5.852–12.328 | 0.000 | 4.854 | 3.198–7.336 | 0.000 |
| M1 (n = 51) | ||||||
| G grade | ||||||
| G1 or G2 (n = 207) | 3.352 | 2.220–5.061 | 0.000 | 2.287 | 1.489–3.513 | 0.000 |
| G3 or G4 (n = 214) | ||||||
| PLCL1 | ||||||
| Low (n = 210) | 0.449 | 0.308–0.654 | 0.000 | 0.674 | 0. 457–0.993 | 0.046 |
| High (n = 211) | ||||||
a)
Multivariate models were adjusted for T, N, M classification, age, and gender
b)
Hazard ratio, estimated from Cox proportional hazard regression model
c)
Confidence interval of the estimated HR.