Table 3.
Pharmacokinetic parameters of gastrodin and 4-HBA.
| Parameters | Gastrodin | 4-HBA | ||
|---|---|---|---|---|
| Vehicle-treated | Antibiotics-treated | Vehicle-treated | Antibiotics-treated | |
| Tmax (h) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.7 ± 0.2 | 0.6 ± 0.1 |
| Cmax (µg/mL) | 26.9 ± 5.3 | 22.9 ± 5.5 | 4.2 ± 1.0 | 2.5 ± 0.8* |
| t1/2 (h) | 0.6 ± 0.0 | 0.6 ± 0.2 | 0.9 ± 0.3 | 1.1 ± 0.3 |
| AUC (µg·h/mL) | 21.8 ± 2.3 | 21.9 ± 1.4 | 7 ± 1.4 | 4.6 ± 1.0* |
| Vd (L/kg) | 1.1 ± 0.2 | 1.6 ± 0.4 | 7.4 ± 1.0 | 14.8 ± 6.6* |
| CL (L/h/kg) | 1.9 ± 0.2 | 1.8 ± 0.1 | 5.8 ± 1.4 | 9.0 ± 2.0* |
Vehicle- and antibiotics-pretreated rats were administered orally with gastrodin at 40 mg/kg. Each value represents the mean ± S.D. of five animals. An asterisk (*) indicates the value is significantly different from the vehicle-treated control at p < 0.05.