Table 1.

Role of Sec22 in different organisms.

Organism	Functions of Sec22 (Other than Anterograde and Retrograde Trafficking)	References
Saccharomyces cerevisiae	Uptake of caesium ions, cellulase secretion, maintenance of ER morphology and autophagy	[54,92,93]
Sordaria macrospora	Effects sexual, asexual reproduction, regulation of ER associated proteins, melanin biosynthesis, and development related genes	[65]
Colletotrichum orbiculare	Transport of virulence related effectors	[64]
Fusarium graminearum	Effects sexual, asexual reproduction and pathogenicity	(unpublished data)
Magnaporthe oryzae	Effects cell wall integrity, growth, reproduction, pathogenicity, chitin deposition, regulation of reactive oxygen species (ROS) level, endocytosis, expression of extracellular enzymes	[58]
Verticilium dahliae	Regulates enzymatic cell wall degradation and pathogenicity	[66]
Arabidopsis thaliana	Gametophyte development and uptake of caesium	[92]
Nicotiana tabacum	Overexpression causes collapse of Golgi membrane proteins into ER	[71]
Drosophila melanogaster	Eye morphogenesis, wingless signaling pathway, Sec22 mutation causes abnormal ER, and Golgi morphology	[17,18]
Mammals (Homo sapiens, Rattusnorvegicus, Mus musculus)	Autophagy, regulate cell motion, protein trafficking, translocation, and downregulation in the hippocampus of aging and Alzheimer’s disease brains	[72,84,86]
Caenorebditis elegans	Regulates RNAi	[90]
Pasmodium falciparum	Encompasses signals for ER/Golgi recycling and fractional export beyond the ER/Golgi interface	[91]