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. 2019 Apr 7;11(4):170. doi: 10.3390/pharmaceutics11040170

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The evaluation of the membrane toxicity of Caco-2 cells monolayers in the existence of SLG-30, sodium glycocholate, and sodium laurate and (B) the relationship between the effects of SLG-30 and typical absorption enhancers on the CF permeability across Caco-2 cells and their toxic effects: The results are expressed as the mean ± S.E. (n = 6). ** p < 0.01, n.s. not significantly different when compared with the control. Keys for Figure 6B: (◯) Control, (∆) 0.001% (v/v) SLG-30, () 0.01% (v/v) SLG-30, (■) 0.025% (v/v) SLG-30, (▲) 0.05% (v/v) SLG-30, (●) 0.1% (v/v) SLG-30. (◆) 0.1% (w/v) sodium glycocholate, (□) 1% (w/v) sodium glycocholate, and (◆) 0.05% (w/v) sodium laurate.

Inline graphic — (A) The evaluation of the membrane toxicity of Caco-2 cells monolayers in the existence of SLG-30, sodium glycocholate, and sodium laurate and (B) the relationship between the effects of SLG-30 and typical absorption enhancers on the CF permeability across Caco-2 cells and their toxic effects: The results are expressed as the mean ± S.E. (n = 6). ** p < 0.01, n.s. not significantly different when compared with the control. Keys for Figure 6B: (◯) Control, (∆) 0.001% (v/v) SLG-30, () 0.01% (v/v) SLG-30, (■) 0.025% (v/v) SLG-30, (▲) 0.05% (v/v) SLG-30, (●) 0.1% (v/v) SLG-30. (◆) 0.1% (w/v) sodium glycocholate, (□) 1% (w/v) sodium glycocholate, and (◆) 0.05% (w/v) sodium laurate.