Table 1.
A summary of the pharmacokinetic parameters of CF (0.5 mg/kg) after its administration with 0.5% (v/v) SLG-30, 0.5% (w/v) sodium laurate, and 1% (w/v) sodium glycocholate into rat small intestines by an in situ closed-loop method.
| Absorption Enhancer | Conc. | Cmax (ng/mL) |
Tmax (min) |
AUC0→240 (ng·min/mL) |
Enhancement Ratio |
|---|---|---|---|---|---|
| Control | - | - | 5450 ± 700 | - | |
| SLG-30 | 0.5% (v/v) | 487 ± 4 | 180 ± 0 | 87,200 ± 6000 ** | 16.0 |
| Sodium laurate | 0.5% (w/v) | 375 ± 2 | 15 ± 0 | 14,700 ± 1950 | 2.7 |
| Sodium glycocholate | 1% (w/v) | 172 ± 2 | 180 ± 0 | 24,500 ± 3700 * | 4.5 |
The results are expressed as the mean ± S.E. (n = 3). ** p < 0.01, * p < 0.05, when compared with the control group.