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. 2019 Mar 31;8(4):298. doi: 10.3390/cells8040298

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

miR-1306 mediates SMAD4 feedback regulation of the classical TGF-β/SMAD signaling pathway. Results of Western blot analysis showing the TGFBR2 protein level after (A) SMAD4- small interfering RNAs (SMAD4-siRNA) was transfected into miR-1306-inhibited GCs and after (B) pcDNA3.1-SMAD4 was transfected into miR-1306-overexpressed GCs. (C) miR-1306 expression levels in GCs were measured after TGF-β1 (20 ng/mL) treatment. (D) The SMAD4/miR-1306/TGFBR2 axis is involved in SMAD4-mediated positive feedback regulation in classical TGF-β/SMAD signaling pathway. Each experiment was independently repeated thrice and the results are presented as mean ± SEM. * p means <0.05 and ** means p < 0.01.