Table 4.
Study Participant | Δ9-THC | Symptom |
male 1 | ‘I was so stressed, irritable, and prone to anger that I started an argument with my partner the afternoon after the study’ | Hostility, irritability, mood lability |
male 2 | ‘I feel I am all over the place and can’t stop laughing, thinking you will expose me, I will say something stupid or strange’ | Conceptual disorganization, thought disorder, loosening of associations, excitement |
male 3 | ‘I can’t follow my thoughts, I am not able to think’ | Conceptual disorganization, racing thoughts |
male 3 | ‘I can understand things better and look for details, I am superior to others’ | Grandiosity |
male 3 | ‘I might have done something wrong, not willing to say’ | Feelings of guilt |
male 3 | ‘I am thinking about death and cemeteries’ | Unusual thought content |
male 6 | ‘The injection changed me into someone with increased abilities’ | Grandiosity |
male 7 | ‘I am feeling quite confused and disoriented, like time is passing slower and the space is different, like from a camera zoom’ | Conceptual disorganization, disorientation |
female 1 | ‘I am not interested and I am not willing to talk, I don’t care, I want just to go... I feel down, under the weather; maybe I am depressed’ | Negative symptoms, depression |
female 4 | ‘What have you done to me? I understand, you want to make me paranoid with brainwashing questions...’ | Suspiciousness/paranoia with loss of insight |
female 4 | ‘What an apple and a ball have in common...You can eat the apple, but not the ball’ | Difficulty in abstract thinking |
female 5 | ‘I thought you were going to attack me, people are entering the room to check on me’ | Suspiciousness/paranoia, ideas of reference |
female 7 | ‘What an apple and a ball have in common...You can put the apple in the ball’ | Difficulty in abstract thinking |
female 8 | ‘My mind went blank, empty, with no thoughts’ | Thought blocking |
female 8 | ‘The ventilator’s noise is louder...This noise is actually rain, it’s raining inside the room, I can see and feel it, there is a black sky with seven blue drops, I can count them, someone has opened the ceiling to let the rain in, and put my bed closer to the ceiling...Maybe someone is projecting a sky in front of me’ | Inability to ‘filter’ out irrelevant background stimuli, hallucinatory behavior, secondary delusions |
female 9 | ‘Is this real? Is this a fake interview made by a fake doctor, like a Truman show?’ | Depersonalization/derealization |
female 9 | ‘Colors are brighter, noises louder, and I have something making a noise in the back of my head’ | Hallucinatory behavior |
male 3, 7; female 5, 7 | ‘I think I am going to chock up...something is wrong with my body...the heart is racing’ | Preoccupation/somatic concern, anxiety/tension |
Study Participant | Placebo | Symptom |
male 7 | ‘I felt spaced out, a little bit paranoid and upset after a conversation with someone who had a strange facial expression’ | Suspiciousness/paranoia |
Δ9-THC, (−)-trans-Δ9-tetrahydrocannabinol.