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ApoA-IV improves glucose homeostasis. (A) ApoA-IV acts downstream of Ca2+-dependent insulin secretion likely via cAMP pathway. (B) ApoA-IV activates PI3K-mediated Akt phosphorylation and eventually promotes Glut4 translocation to the plasma membrane for glucose uptake in adipocytes. (C) ApoA-IV interacts with NR1D1 or NR4A1 in the nucleus to downregulate the expressions of PEPCK and G6Pase, which are involved in hepatic gluconeogenesis.
