Figure 9.
Effect of NGF and NGF(1-14) peptides on the brain-derived neurotrophic factor (BDNF) secretion. Starved PC12 cells were stimulated for 24 h with 50 ng/mL of NGF or 10 μM of NGF(1-14) peptides in the absence (☐) or in the presence of CuSO4 (■) or BCS (■). Cell culture mediums were collected and analyzed by ELISA BDNF kit. Data obtained from at least three independent experiments (* p < 0.05, *** p < 0.001 versus control; §§§ p < 0.001 versus CuSO4; ### p < 0.001 versus BCS; one-way Anova).