Figure 2.

Trichome formation on Drosophila legs is repressed by miR-92a. The TF Shavenbaby (Svb) controls the expression of multiple genes whose products lead to the formation of trichomes (grey) via promotion of actin condensation and changes in the extracellular matrix. Some of these genes (sha and CG14395) have been shown to be repressed by miR-92a, and others are likely targets. The targeting of these genes by miR-92a results in a robust suppression of trichome development in the proximal region of the second leg femur where miR-92a is expressed (the naked valley; white). miR-92a expression is possibly activated by Ubx.