Table 2.
Computed budesonide (BUD) and formoterol (FF) particle size fractions characteristic of different disease severity groups. ED—emitted dose; f1, f3, f5, f7, and f10—mass size fractions of <1 μm, <3 μm, <5 μm, <7 μm, and <10 μm particles, respectively; flarge—fraction of large particles; MMAD—mass median aerodynamic diameter; GSD—geometric standard deviation.
| Aerosol Parameter | Severe COPD | Moderate COPD | Mild COPD | |||
|---|---|---|---|---|---|---|
| BUD | FF | BUD | FF | BUD | FF | |
| ED (%) | 49.74 | 37.13 | 60 | 51.29 | 68.30 | 62.73 |
| f1 (%) | 1.87 | 1.83 | 3.64 | 3.25 | 5.07 | 4.39 |
| f3 (%) | 8.33 | 6.09 | 18.95 | 16.53 | 27.53 | 24.97 |
| f5 (%) | 16.46 | 15.77 | 27.56 | 25.56 | 36.53 | 33.47 |
| f7 (%) | 21.73 | 22.55 | 34.11 | 32.93 | 42.44 | 38.82 |
| f10 (%) | 23.05 | 25.23 | 36.09 | 35.68 | 44.85 | 40.49 |
| flarge (%) | 26.69 | 11.9 | 23.91 | 15.61 | 23.45 | 22.24 |
| MMAD (μm) | 3.03 | 3.44 | 2.67 | 2.87 | 2.45 | 2.43 |
| GSD (–) | 2.02 | 2.23 | 1.87 | 1.91 | 1.81 | 1.80 |