Table 3.
Computed deposition fractions with standard deviations in the inhaler (DEV), upper airways (ET), lungs (LUNG, bronchial, bronchiolar and acinar airways) and the exhaled fraction (EXH) of both drug components in different disease category groups.
| Dose Fractions | Severe COPD | Moderate COPD | Mild COPD | |||
|---|---|---|---|---|---|---|
| BUD | FF | BUD | FF | BUD | FF | |
| DEV (%) | 50.3 ± 8.1 | 62.9 ± 7.3 | 40.0 ± 4.3 | 48.7 ± 4.4 | 31.7 ± 5.1 | 37.3 ± 4.8 |
| ET (%) | 27.3 ± 4.6 | 16.3 ± 4.5 | 31.7 ± 3.8 | 24.7 ± 3.7 | 34.8 ± 4.8 | 32.2 ± 5.0 |
| LUNG (%) | 17.7 ± 4.8 | 16.4 ± 4.5 | 23.8 ± 5.5 | 22.6 ± 5.6 | 29.7 ± 3.7 | 27.1 ± 3.9 |
| EXH (%) | 4.6 ± 1.1 | 4.4 ± 1.8 | 4.5 ± 1.6 | 4.1 ± 1.9 | 3.8 ± 1.6 | 3.4 ± 1.3 |