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ATG5 downregulates classical interferon-stimulated gene expression. pATG5, pEmpty, Neg gRNA and ATG5 gRNA were transfected into Huh7.5.1 cells. The selected gene mRNAs were assessed by qPCR. (A) Overexpression of pATG5 decreases MX1 mRNA levels; (B) overexpression of pATG5 decreases OAS3 mRNA levels; (C) ATG5 gRNA increases MX1 mRNA levels; and (D) ATG5 gRNA increases OAS3 mRNA levels. Data are expressed as mean ± SD of at least three sample replicates. * p < 0.05, ** p < 0.01.
