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. 2019 Apr 23;8(4):369. doi: 10.3390/cells8040369

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of RGs on the abundance of miRNAs differentially expressed between iASC-EVs samples. (A) After normalization with stable miR-26a-5p/16-5p, out of 48 assayed miRNAs only miR-138-5p, miR-181a-5p, and miR-483-5p showed significant differential expression (±4 fold changes) between samples. iASC-EVs 01 set as 1; * p-value < 0.05 and ** p-value < 0.01. (B) Using miR-103a-3p/425-5p on miR-138-5p, both expression ratios (EVs 02 vs. 01 or EVs 03 vs. 04) and significance (EVs 03 vs. 05) are lost.