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. 2019 Apr 12;8(4):99. doi: 10.3390/antiox8040099

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the treatment plan for the xenograft mouse model. Cultured Eker rat-derived uterine leiomyoma cells transfected with luciferase (ELT-3-LUC) embedded in Dulbecco’s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12)/Matrigel solution were transplanted into the right flank of female nude (Foxn1^nu) mice. When the tumors reached a size of 50–100 mm³ (approximately 1 month), the mice received an intraperitoneal injection of either resveratrol (RSV; 10 mg·kg⁻¹) or vehicle control (dimethyl sulfoxide; DMSO) twice a week for 1 month. nude (Foxn1^nu) mice: nude mice with a spontaneous deletion in the FOXN1 gene; IVIS: non-invasive in vivo imaging system; H&E: hematoxylin and eosin; IHC: immunohistochemical.