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. 2019 Apr 7;8(4):93. doi: 10.3390/antiox8040093

Figure 2.

Figure 2

Mitochondrial respiration in ischemic and non-ischemic gastrocnemius in mice treated (n = 10) or not (n = 8) with sildenafil; (a): V0 corresponds to the basal O2 consumption, with glutamate and malate as substrates. (b): V max corresponds to the ADP-stimulated respiration, with glutamate and malate as substrates. (c): Vsucc represents the activation of all complexes (I, II, III, IV, V). (d): Vasc/TMPD represents the complex IV contribution to the global mitochondrial respiratory rate. For both NaCl and Sildenafil groups: left column, non-ischemic contralateral limb. Right column: Ischemic limb. Results are expressed as means ± SEM. *: p < 0.05; **: p < 0.01 and ***: p < 0.001, as compared to the contralateral limb of the same group.