Figure 10.

In vivo siRNA therapy of KB tumor xenografts with FA-PEG-modified PLK1 siRNA lipoplexes in mice. When the average volume of the xenograft tumors reached 80 mm³ (day 0), LP-HAPC-2mol%PEG₂₀₀₀ and LP-HAPC-2mol%FA-PEG₂₀₀₀ lipoplexes with 10 μg of Cont siRNA or PLK1 siRNA were injected directly into the tumor three times (day 0, 2, and 4). Tumor volume was measured at days 0, 2, 4, 6, and 8 (A). Tumor volume (%) was calculated as relative to each tumor volume at the day 0. The mice were sacrificed at day 8, and then the excised tumors were weighed (B). Each result represents the mean + SD (n = 3–4).