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. 2019 Mar 29;9(4):128. doi: 10.3390/biom9040128

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The resistance of human transthyretin in the absence or presence of CAB against acid-mediated denaturation. HuTTR (0.5 µg/µL) was incubated with or without CAB (50 µg/µL) and subjected to acidic denaturation conditions for 2 weeks. (a) The image represents the resolved protein mixtures on 10% Tricine SDS-PAGE gels after cross-linking with glutaraldehyde. M: Protein molecular weight marker; 1: huTTR with GMSO only, pH 4.0; 2: huTTR with CAB, pH 4.0; 3: huTTR with GMSO only, pH 7.0. (b) Bar chart represents the extent of huTTR stability, derived from the percentage of tetramers (%) left after denaturation. * values are significantly different at p < 0.05.