Table 4.

Metabolites associated with FEV1/FVC at FDR < 0.05 in meta-analysis *.

		Meta-Analysis				ARIC African Ancestry (n = 2354)			ARIC European Ancestry (n = 1529)			KORA (n = 859)
Metabolite	Super Pathway	Beta +	SE	P	Direction **	Beta	SE	P	Beta	SE	P	Beta	SE	P
3-methoxytyrosine	Amino Acid	−0.42	0.10	5.0 × 10−5	−−−	−0.37	0.13	4.1 × 10−3	−0.45	0.35	2.0 × 10−1	−0.53	0.20	8.1 × 10−3
androsterone sulfate	Lipid	0.37	0.10	2.5 × 10−4	+++	0.29	0.16	7.9 × 10−2	0.31	0.17	7.0 × 10−2	0.57	0.20	5.6 × 10−3
glycerol	Lipid	−0.36	0.11	8.6 × 10−4	−−−	−0.27	0.16	9.1 × 10−2	−0.52	0.20	7.4 × 10−3	−0.32	0.22	1.4 × 10−1
dehydroisoandrosterone sulfate (DHEA-S)	Lipid	0.35	0.11	1.2 × 10−3	+++	0.39	0.17	2.1 × 10−2	0.37	0.19	5.1 × 10−2	0.27	0.22	2.2 × 10−1
lathosterol	Lipid	0.34	0.10	7.4 × 10−4	+++	0.38	0.15	1.3 × 10−2	0.37	0.18	4.1 × 10−2	0.24	0.20	2.5 × 10−1
oleoylcarnitine	Lipid	−0.42	0.10	2.9 × 10−5	−−−	−0.46	0.15	2.1 × 10−3	−0.50	0.18	4.8 × 10−3	−0.23	0.20	2.7 × 10−1
7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)	Lipid	−0.33	0.10	9.6 × 10−4	−−−	−0.32	0.16	3.8 × 10−2	−0.28	0.17	1.1 × 10−1	−0.42	0.21	4.0 × 10−2
theophylline	Xenobiotics	−0.62	0.10	4.0 × 10−10	−−−	−0.72	0.14	4.8 × 10−7	−0.73	0.18	7.5 × 10−5	−0.26	0.21	2.1 × 10−1

* Metabolites measured in all three populations were shown in this table. All metabolites associations with FEV1/FVC were shown in Supplementary Table S6. ⁺ Regression coefficient: difference in FEV1/FVC (scaled as a percentage) per SD change in the metabolite levels. ** Direction of effect: the first, second and third +, or − refers to the direction of effect in ARIC African ancestry, ARIC European ancestry and KORA.