Table 1.
Cyclin-Dependent Kinases (CDK)4/6 inhibitors’ toxicity profiles.
| Palbociclib | Ribociclib | Abemaciclib | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Monotherapy [46] | +letrozole PALOMA-2 [47] | +fulvestrant PALOMA-3 [48] | Monotherapy [49] | +letrozole MONALEESA-2 [43] | +fulvestrant MONALEESA-3 [50] | Monotherapy MONARCH-1 [44] | +fulvestrant MONARCH-2 [45] | +letrozole/anastrozole MONARCH-3 [51] | |
| Adverse Event (any grade) | Neutropenia (92%) | Neutropenia (80%) | Neutropenia (80%) | Neutropenia (46%) | Neutropenia (75%) | Neutropenia (70%) | Neutropenia (85%) | Neutropenia (46%) | Neutropenia (41%) |
| Leukopenia (100%) | Leukopenia (40%) | Leukopenia (50%) | Leukopenia (43%) | Leukopenia (33%) | Nausea (45%) | Leukopenia (90%) | Diarrhea (86%) | Diarrhea (81%) | |
| Thrombocytopenia (76%) | Nausea (35%) | Infections (42%) | Thrombocytopenia (30%) | Nausea (50%) | Fatigue (32%) | Thrombocytopenia (76%) | Nausea (45%) | Nausea (39%) | |
| Anemia (70%) | Fatigue (35%) | Fatigue (40%) | Fatigue (45%) | Infections (50%) | Diarrhea (29%) | Anemia (69%) | Fatigue (40%) | Fatigue (40%) | |
| Lymphopenia (65%) | Arthralgia (33%) | Nausea (32%) | Nausea (42%) | Fatigue (37%) | Leukopenia (28%) | Diarrhea (90%) | Abdominal pain (35%) | Infections (39%) | |
| Alopecia (33%) | Diarrhea (35%) | Vomiting (27%) | Fatigue (65%) | ||||||
| Alopecia (33%) | Constipation (25%) | Nausea (65%) | |||||||
| Arthralgia (24%) | Decreased appetite (45%) | ||||||||
| Cough (22%) | Abdominal pain (40%) | ||||||||
| Headache (22%) | Vomiting (35%) | ||||||||
| Alopecia (19%) | |||||||||
| Rash (18%) | |||||||||
| Anemia (17%) | |||||||||
| Adverse Event (grade 3–4) | Neutropenia (54%) | Neutropenia (66%) | Neutropenia (65%) | Neutropenia (27%) | Neutropenia (59%) | Neutropenia (53%) | Neutropenia (27%) | Neutropenia (24%) | Neutropenia (21%) |
| Leukopenia (51%) | Leukopenia (25%) | Leukopenia (28%) | Leukopenia (17%) | Leukopenia (21%) | Leukopenia (14%) | Leukopenia (28%) | |||
| Lymphopenia (30%) | Fatigue (2%) | Anemia (3%) | Diarrhea (20%) | ||||||
| Nausea (2%) | Fatigue (2%) | ||||||||
| Back Pain (2%) | |||||||||
| Nausea (1%) | |||||||||
| Constipation (1%) | |||||||||
| Headache (1%) | |||||||||