Figure 8.

Verification of an opened BBB at the focused ultrasound target. (A) Aimed position of the focal spot of the FUS transducer, projected on a T₂w anatomical image. (B) Post- minus pre-contrast T₁w image showing signal enhancement in the area that was treated with focused ultrasound (arrow). The observed in-plane cross-section of the disrupted area was approximately 7 mm². (C) IgG staining of a cross-sectional slice at the height of the focal spot (dashed red line). Brown color indicates immunoglobulin G that leaked into the tissue from the blood. (D) IgG staining of a cross-sectional slice at the height of the dashed green line. No leakage was observed.