Table 4.
Baseline and two-year follow-up lung function, haemodynamic data, and exercise capacity in COPD patients and comparators.
| COPD (n = 301) | Comparators (n = 105) | p-Value | ||||
|---|---|---|---|---|---|---|
| Baseline | Two Years | p = | Baseline | Two Years | ||
| FEV1 (L) | 1.41 ± 0.59 | 1.34 ± 0.60 | <0.001 | 2.73 ± 0.69 | 2.63 ± 0.69 | <0.001 |
| FVC (L) | 2.68 ± 0.88 | 2.49 ± 0.91 | <0.001 | 3.48 ± 0.91 | 3.37 ± 0.94 | 0.001 |
| FEV1 FVC (L) | 0.52 ± 0.12 | 0.54 ± 0.13 | 0.001 | 0.79 ± 0.05 | 0.78 ± 0.05 | 0.387 |
| FEV1 % | 58 ± 19 | 57 ± 21 | 0.174 | 106 ± 14 | 104 ± 19 | 0.124 |
| SBP (mmHg) | 147 ± 19 | 143 ± 19 | <0.001 | 140 ± 18 | 137 ± 16 | 0.032 |
| DBP (mmHg) | 82 ± 10 | 80 ± 10 | <0.001 | 80 ± 9 | 80 ± 8 | 0.294 |
| Central MAP (mmHg) | 98 ± 12 | 98 ± 11 | 0.208 | 95 ± 11 | 94 ± 11 | 0.775 |
| Aortic PWV (m/s) | 10 ± 2.3 | 10.5 ± 2.6 | <0.001 | 8.3 ± 1.7 | 8.8 ± 1.8 | 0.000 |
| Cardiac output (L/min)/# | 5.8 ± 1.2 | 5.9 ± 1.3 | 0.084 | 5.9 ± 1.1 | 6.1 ± 1.4 | 0.109 |
| Cardiac index (L/min/m2) # | 3.2 ± 0.5 | 3.3 ± 0.6 | 0.005 | 3.1 ± 0.5 | 7.6 ± 39.5 | 0.250 |
| Stroke volume (mLs) # | 87 ± 20 | 87± 22 | 0.882 | 95 ± 21 | 99 ± 24 | 0.063 |
| 6-MWD (m) ~ | 359 ± 110 | 332 ± 149 | <0.001 | 508 ± 83 | 496 ± 80 | 0.107 |
Data are mean ± SD; # = COPD (n = 284); ~ = COPD (n = 264); comparator (n = 100); p < 0.05 significant difference within groups; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; PWV = pulse wave velocity; SBP = systolic blood pressure; DBP = diastolic blood pressure; PP = pulse pressure; MAP = mean arterial pressure; 6-MWD = six-minute walk distance.