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Dynamics of the thermal and mechanical withdrawals. Intra-plantar injection of Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL) results in a significant decrease of the thermal paw latency (A) and mechanical paw threshold (C), i.e., develops hyperalgesia. There are weaker mirror hyperalgesic effects for the contralateral paw (B,D). BL, pre-injection baseline. Note, there are no dose-dependent effects of SLIGRL on hyperalgesia (A,C).
