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Schematic overview of SB and SPB metabolism. Sodium phenylbutyrate is oxidized into phenylacetate. Phenylacetate conjugates with glycine to form phenylacetylglycine (PAG) and SB conjugates with glycin to form hippuric acid (HA). Hippuric acid and PAG are excreted in the urine, each removing one nitrogen molecule. SB, sodium benzoate, SPB, sodium phenylbutyrate Modified from Misel et al23
