Table 3.
Glutathione S‐transferase (GST)‐theta genotype and minor allele frequencies (MAFs) in dogs with transitional cell carcinoma (TCC) and in older breed‐ and sex‐matched control dogs. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated relative to the reference genotype or allele
| GST locus | TCC | Controls | OR | 95% CI | P value |
|---|---|---|---|---|---|
| GSTT1 I2+28 | 66 dogs | 68 dogs | |||
| Genotype (n) | |||||
| GG (REF) | 56 | 56 | 0.83 | 0.32‐2.02 | .82 |
| GA | 8 | 11 | |||
| AA | 2 | 1 | |||
| MAF | 0.091 | 0.096 | 0.95 | 0.40‐2.15 | 1.00 |
| GSTT1 3′UTR haplotype | 69 dogs | 68 dogs | |||
| Genotype (n) | |||||
| REF | 53 | 50 | 0.84 | 0.39‐1.85 | .70 |
| HET insT | 12 | 14 | |||
| HOM insT | 4 | 4 | |||
| MAF | 0.145 | 0.162 | 0.74 | 0.46‐1.66 | .74 |
| GSTT5 exon 4 6 bp del | 68 dogs | 67 dogs | |||
| Genotype (n) | |||||
| REF | 61 | 64 | 2.45 | 0.63‐8.97 | .33 |
| HET Del | 7 | 3 | |||
| HOM Del | 0 | 0 | |||
| MAF | 0.051 | 0.022 | 2.37 | 0.64‐8.55 | .33 |