Table 2.

Logistic regression of predictors for MRA initiation by cohort in the CKD population

Independent variables	CKD				DKD				CKD + HF				DKD + HF
	Odds ratio	Confidence interval		P value	Odds ratio	Confidence interval		P value	Odds ratio	Confidence interval		P value	Odds ratio	Confidence interval		P value
		Lower limit	Upper limit			Lower limit	Upper limit			Lower limit	Upper limit			Lower limit	Upper limit
Age, years (vs 18–34 years)
35–44	1.93	1.43	2.61	< 0.0001	1.15	0.72	1.82	0.5666	0.82	0.50	1.34	0.4255	1.10	0.47	2.53	0.83
45–54	1.48	1.11	1.96	0.0075	1.01	0.66	1.55	0.9672	0.98	0.64	1.51	0.9423	1.31	0.60	2.85	0.50
55–64	1.31	0.99	1.73	0.0593	0.90	0.59	1.37	0.6131	0.70	0.46	1.06	0.0897	1.14	0.53	2.48	0.73
65+	0.95	0.71	1.27	0.7419	0.63	0.41	0.98	0.0381	0.40	0.27	0.61	< 0.0001	0.80	0.37	1.74	0.58
Sex (vs male)
Female	1.43	1.28	1.59	< 0.0001	1.04	0.93	1.16	0.4554	0.77	0.66	0.89	0.0004	0.83	0.73	0.93	0.002
Prescribing physician specialty at inclusion (vs general/family practice)
Internal Medicine	1.04	0.86	1.26	0.695	1.25	1.03	1.52	0.0266	1.03	0.77	1.39	0.8268	1.30	1.02	1.66	0.03
Cardiology	1.28	0.93	1.75	0.126	1.11	0.78	1.59	0.5677	1.36	0.97	1.92	0.0789	1.79	1.34	2.40	< 0.0001
Nephrology	1.45	1.22	1.73	< 0.0001	1.76	1.47	2.10	< 0.0001	1.27	0.95	1.70	0.1068	1.11	0.88	1.41	0.38
Hospital	1.69	1.38	2.07	< 0.0001	1.49	1.21	1.85	0.0002	2.09	1.61	2.73	< 0.0001	1.68	1.34	2.11	< 0.0001
Other/unknown	1.34	1.12	1.601	0.0017	1.24	1.02	1.51	0.0288	1.50	1.15	1.95	0.0027	1.30	1.03	1.63	0.02
Previous medication use (yes vs no)
ARBs	1.75	1.55	1.97	< 0.0001	1.62	1.44	1.82	< 0.0001	1.40	1.19	1.65	< 0.0001	1.34	1.18	1.52	< 0.0001
ACE inhibitors	1.24	1.10	1.39	0.0003	1.37	1.22	1.54	< 0.0001	1.33	1.16	1.54	< 0.0001	1.34	1.19	1.51	< 0.0001
Renin inhibitors	2.11	1.44	3.10	0.0001	1.66	1.21	2.27	0.0016	1.28	0.65	2.52	0.476	1.25	0.83	1.890	0.28
Vasodilators	2.20	1.92	2.53	< 0.0001	1.64	1.45	1.86	< 0.0001	1.25	1.06	1.46	0.0066	0.97	0.85	1.09	0.59
Comorbidities
LVH	1.26	0.97	1.65	0.0884	1.71	1.39	2.09	< 0.0001	1.71	1.46	2.000	< 0.0001	1.28	1.11	1.46	0.0005
Anemia	1.07	0.94	1.21	0.2916	0.84	0.74	0.95	0.0063	0.72	0.62	0.84	< 0.0001	0.70	0.62	0.79	< 0.0001
Edema	2.14	1.85	2.47	< 0.0001	2.09	1.83	2.38	< 0.0001	1.48	1.26	1.73	< 0.0001	1.47	1.30	1.66	< 0.0001
Proteinuria	1.18	1.00	1.41	0.0571	1.31	1.13	1.51	0.0004	0.82	0.59	1.15	0.2475	0.98	0.80	1.20	0.85
Hyperkalemia	0.96	0.71	1.30	0.8046	0.55	0.42	0.73	< 0.0001	0.49	0.34	0.70	0.0001	0.57	0.45	0.71	< 0.0001
Sensitivity testing: c-statistic	0.67				0.66				0.68				0.63

ACE acetylcholinesterase, ARB angiotensin II receptor blocker, CKD chronic kidney disease, DKD diabetic kidney disease, HF heart failure, LVH left ventricular hypertrophy, MRA mineralocorticoid receptor antagonist