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. 2019 May 16;38:198. doi: 10.1186/s13046-019-1213-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — HCC-associated lncRNAs in histone modification. a HCC-associated lncRNAs recruit histone modifiers to regulate gene expression. Left panel: HOTAIR suppresses miR-218 expression by recruiting PRC2 to miR-218 promoter, which induces chromatin remodeling and H3K27 trimethylation. Right panel: decreased HORAIR inhibits PRC2-mediated miR-218 transcription suppression. b HCC-associated lncRNAs act as scaffold to bridge histone modifiers to regulate gene expression. Left panel: HOTAIR bridges PRC2 complex and Snail, which leads to H3K27 trimethylation in promoter region of Snail target genes. Right panel: decreased HORAIR inhibits PRC2-mediated transcription suppression of Snail target genes