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. 2019 May 16;38:198. doi: 10.1186/s13046-019-1213-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — HCC-associated lncRNAs in DNA methylation modification. Upper panel: linc00441 suppresses RB1 expression by recruiting DNMT3A to RB1 promoter, which induces DNA methylation of RB1 promoter. Lower panel: decreased linc00441 inhibits DNMT3A-mediated RB1 transcription suppression