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. 2019 May 16;38:198. doi: 10.1186/s13046-019-1213-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — HCC-associated lncRNAs in mRNA post-transcriptional regulation. a Left panel: PXN-AS1-L can sequester miR-24 with its exon4, thereby increasing PXN mRNA stability. Right panel: PXN-AS1-S does not consist of exon4, which releases miR-24 to bind to PXN mRNA 3’UTR. b Left panel: HULC can increase CLOCK mRNA stability by binding to its 5’UTR. Right panel: decreased HULC expression impairs CLOCK expression. c Left panel: lncRNA-ATB can increase ZEB1/2 mRNA stability by sequestering miR-200 s. Also, lncRNA-ATB can increase IL-11 mRNA stability by binding with it. Right panel: decreased lncRNA-ATB expression impairs ZEB1/2 and IL-11 expression. d Left panel: HuR can stabilize β-catenin by binding to its 3’UTR. Right panel: MIR22HG can down-regulate β-catenin mRNA by sequestering β-catenin mRNA