Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 16;38:198. doi: 10.1186/s13046-019-1213-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 5 — HCC-associated lncRNAs in protein degradation. a Upper panel: LINC01138 blocks E3 ligase CHIP-mediated ubiquitination of PRMT5 by sequestering PRMT5. Lower panel: decreased LINC01138 leads to release of PRMT5, which leads to E3 ligase CHIP-mediated ubiquitination of PRMT5 and its degradation. b Upper panel: HOTAIR acts as scaffold to bridge E3 ligase Mex3b and SUZ12, a core subunit of PRC2 complex, which leads to ubiquitination and degradation of SUZ12. Lower panel: DDX5 inhibits E3 ligase Mex3b-mediated SUZ12 protein degradation by displacing the Mex3b from HOTAIR