Fig. 4.

Prognostic significance of the macrophage-related gene signature in the learning and validation sets. a K–M survival analysis of glioma patients in the learning set. A risk score was formulated from the COX PH model based on the gene expression levels of the 12 selected genes. The patients were divided into the high-risk group (blue) and low-risk group (red). The statistical significance of the difference between two K–M survival curves was assessed using the log-rank test, with p values less than 0.0001. b Prognostic accuracy of the signature evaluated by the AUCs of the time-dependent ROCs with respect to the 3- and 5-year survival rates of glioma patients in the learning set. c Prognostic significance of the macrophage-related gene signature validated by the independent validation set. p values were less than 0.0001, as assessed by the log-rank test. d Prognostic accuracy of the macrophage-related gene signature validated by the AUCs of the time-dependent ROCs with respect to the 3- and 5-year survival rates of glioma patients in the independent validation set