Fig. 6.

Robustness tests of the macrophage-related gene signature compared with signatures identified by LASSO Cox regression model (a–c) and correlation-network-based method (d–e). We generated 100 random datasets by randomly taking 60% of the samples from the validation set. The AUC values of ROC with respect to overall survival (a, d), 3-year survival (b, e) and 5-year survival (c, f) were computed. Wilcoxon rank sum test (one-tailed) p values were computed to assess the significance of the difference between the probability distributions of AUC values of the macrophage-related gene signature and the LASSO Cox signature or correlation-network-based signature. The macrophage-related gene signature showed good robustness and better accuracy than the LASSO Cox signature or correlation-network-based signature