Fig. 1.

Study design and primary focus of original reports included in this review. The boxes on the left side contain a listing of the classification of the 446 original reports divided into the numbers (n) from each of the four journals reviewed. Percentages in the subsequent boxes use the journal-specific number (n) from the previous box as the reference. The boxes on the right side are the different exclusion criteria applied to the original reports to obtain the final cohort of 66 Phase III RCTs with time to event primary outcomes reviewed. Percentages in each exclusion criteria box use the total number (n) of exclusions at that step as the reference