Fig. 2.

AIBP and APOA-I cooperate to inhibit tumor growth and metastasis. a–c Representative images and statistical analyses of tumors in mice inoculated with HCT116 (a) or SW620 cells (b) expressing the negative control (NC), AIBP, APOA-I and AIBP + APOA-I, and the average radiant efficiency [(p/s/cm²/sr]/(μW/cm²)] of tumors in mice (c) (n = 5; *P < 0.05; **P < 0.01). d The tumor growth rates were evaluated by calculating the tumor volume. e Representative tumors from mice injected with HCT116 cells expressing AIBP and subcutaneously administered APOA-I recombinant proteins (R-APOA-I, 0.5 mg/kg) at the end stage (mean ± SD, n = 5; *P < 0.05; **P < 0.01). f Representative picture and HE staining image after injection of the indicated cells. g Liver metastatic foci were quantified (mean ± SD, n = 8, **P < 0.01). h The survival rates of the indicated cell-transplanted mice (n = 6, 8, 8, and 8, respectively). Kaplan-Meier survival curves representing the percentages of live mice on the days indicated. Statistical significance among the studied groups was calculated using GraphPad Prism 6 software