Table 1.
Groups | BBB n = 10 | Infarcted Volume n = 10 | Temperature n = 20 | Mortality n (%) | ||||
---|---|---|---|---|---|---|---|---|
Mean and SEM | Variability% | Mean and SEM % | Variability% | Mean and SEM °C | Variability% | |||
Naïve (n = 20) | 1 section | 80 ± 15 | 58 | 0.5 ± 0.3 | 191 | 37.2 °C ± 0.1 |
59 | 0% |
2 section | 113 ± 20 | 55 | 0.6 ± 0.2 | 86 | ||||
3 section | 174 ± 33 | 60 | 0.4 ± 0.3 | 209 | ||||
4 section | 151 ± 22 | 46 | 0.6 ± 0.3 | 187 | ||||
5 section | 161 ± 33 | 65 | 0.4 ± 0.3 | 250 | ||||
6 section | 127 ± 15 | 37 | 0.6 ± 0.3 | 149 | ||||
Total Hemisphere | 134 ± 11 | 25 | 0.5 ± 0.1 | 77 | ||||
Laser 25jx1 (n = 20) | 1 section | 76 ± 36 | 148 | 1.1 ± 0.4 | 126 | 37.3 °C ± 0.1 |
61 | 0% |
2 section | 83 ± 31 | 120 | 0.4 ± 0.3 | 215 | ||||
3 section | 315 ± 172 | 172 | 1.2 ± 0.4 | 97 | ||||
4 section | 362 ± 118 | 103 | 0.5 ± 0.4 | 252 | ||||
5 section | 310 ± 47 | 48 | 1.4 ± 0.4 | 74 | ||||
6 section | 212 ± 28 | 42 | 0.6 ± 0.3 | 163 | ||||
Total Hemisphere | 234 ± 67 | 90 | 0.9 ± 0.1 | 49 | ||||
Laser 50jx1 (n = 20) | 1 section | 53 ± 43 | 257 | 0.5 ± 0.2 | 142 | 37.3 °C ± 0.1 |
55 | 0% |
2 section | 233 ± 90 | 122 | 0.9 ± 0.3 | 116 | ||||
3 section | 556 ± 180 | 102 | 0.7 ± 0.3 | 115 | ||||
4 section | 418 ± 88a | 67 | 0.8 ± 0.2 | 84 | ||||
5 section | 281 ± 99 | 112 | 0.8 ± 0.3 | 97 | ||||
6 section | 326 ± 90a | 88 | 0.5 ± 0.3 | 173 | ||||
Total Hemisphere | 321 ± 63a | 63 | 0.7 ± 0.1 | 47 | ||||
Laser 50jx2 (n = 20) | 1 section | 89 ± 48 | 170 | 0.9 ± 0.2 | 81 | 37.3 °C ± 0.1 |
54 | 0% |
2 section | 308 ± 67a | 69 | 0.5 ± 0.3 | 203 | ||||
3 section | 1072 ± 295a | 87 | 0.6 ± 0.4 | 199 | ||||
4 section | 1147 ± 260a | 72 | 0.4 ± 0.3 | 223 | ||||
5 section | 1262 ± 207a | 52 | 0.5 ± 0.3 | 170 | ||||
6 section | 853 ± 271a | 100 | 1.1 ± 0.3 | 87 | ||||
Total Hemisphere | 725 ± 100a | 44 | 0.7 ± 0.1 | 48 | ||||
Laser 50jx5 (n = 20) | 1 section | 617 ± 144a | 74 | 2.3 ± 0.4a | 51 | 37.4 °C ± 0.1 |
53 | 0% |
2 section | 854 ± 145a | 53 | 1.3 ± 0.3 | 71 | ||||
3 section | 1114 ± 249a | 71 | 2.0 ± 0.4a | 59 | ||||
4 section | 1585 ± 385a | 77 | 2.8 ± 0.6a | 63 | ||||
5 section | 2027 ± 460a | 72 | 1.2 ± 0.3 | 90 | ||||
6 section | 1332 ± 340a | 81 | 1.7 ± 0.5 | 89 | ||||
Total Hemisphere | 1255 ± 167a | 42 | 1.9 ± 0.5a | 33 | ||||
Laser 50jx10 (n = 20) | 1 section | 1359 ± 367a | 85 | 2.2 ± 0.4a | 58 | 37.4 °C ± 0.1 |
84 | 0% |
2 section | 2011 ± 431a | 68 | 2.4 ± 0.5 | 69 | ||||
3 section | 1977 ± 318a | 51 | 3.3 ± 0.5a | 46 | ||||
4 section | 2632 ± 234a | 28 | 3.8 ± 0.6a | 51 | ||||
5 section | 2644 ± 340a | 41 | 1.6 ± 0.5 | 92 | ||||
6 section | 2600 ± 529a | 64 | 1.3 ± 0.6 | 162 | ||||
Total Hemisphere | 2204 ± 280a | 40 | 2.4 ± 0.3a | 34 | ||||
t-MCAO (n = 25) | 1 section | 371 ± 211 | 179 | 0.5 ± 0.8 | 555 | 38.2 °C ± 0.1a |
121 | 5 (17%) |
2 section | 1053 ± 377a | 113 | 0.1 ± 0.7 | 1618 | ||||
3 section | 1806 ± 507a | 89 | 6.8 ± 3.0 | 141 | ||||
4 section | 2108 ± 262a | 39 | 2.2 ± 1.3a | 192 | ||||
5 section | 2649 ± 688a | 89 | −0.1 ± 0.8 | 4625 | ||||
6 section | 2338 ± 322a | 44 | 2.2 ± 1 | 151 | ||||
Total Hemisphere | 1688 ± 231a | 43 | 1.9 ± 0.8 | 123 | ||||
p-MCAO (n = 24) | 1 section | 355 ± 147 | 131 | 2.6 ± 1.3 | 164 | 38.3 °C ± 0.1a |
129 | 6 (20%) |
2 section | 988 ± 200a | 64 | 9.3 ± 4.7 | 159 | ||||
3 section | 3176 ± 750a | 75 | 19.6 ± 6.6a | 106 | ||||
4 section | 5213 ± 484a | 29 | 16.8 ± 4.6a | 87 | ||||
5 section | 3910 ± 649a | 52 | 7.1 ± 3.6 | 161 | ||||
6 section | 2942 ± 477a | 51 | 4.0 ± 2.8 | 228 | ||||
Total Hemisphere | 2764 ± 256a | 29 | 9.9 ± 2.9a | 92 |