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. 2019 May 10;10:1113. doi: 10.3389/fmicb.2019.01113

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Copyright © 2019 Wang, Zheng, Sun, Feng, Gao, Fan, Chen, Jin and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective efficacy against DENV2 challenge in different immunization regimens. Mice immunized with different regimens were challenged i.c. with DENV2 and monitored daily for body weight and survival rate for 12 consecutive days (n = 8). (A–C) Percentage changes of body weight from day 0 were determined as 100 × (weight post-challenge)/(weight pre-challenge). Data were expressed as mean ± SD, (D–F) The survival rate shown as the percentage of survivors. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001.