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. 2019 May 10;10:1113. doi: 10.3389/fmicb.2019.01113

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Copyright © 2019 Wang, Zheng, Sun, Feng, Gao, Fan, Chen, Jin and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective efficacy against DENV1, DENV3, and DENV4 induced by the DDP immunization regimen. Mice immunized with the DDP regimen were challenged i.c. with DENV1, DENV3, and DENV4 and monitored daily for 12 days (n = 8). Percentage changes of body weight from day 0 after challenge with (A) DENV1, (B) DENV3, and (C) DENV4. The percentage was determined as 100 × (weight post-challenge)/(weight pre-challenge). Data were expressed as mean ± SD. (D) The survival rate post challenge with DENV4 was shown as the percentage of survivors. ^∗P < 0.05, ^∗∗P < 0.01.