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. 2019 May 10;10:1057. doi: 10.3389/fimmu.2019.01057

Figure 4.

Figure 4

Inhibition of chitin-mediated airway eosinophil recruitment by adiponectin. BALB/c (A–E) or C57BL/6 wild-type (WT) or adiponectin-deficient (APKO) (F–J) mice aspirated chitin particles as described for Figure 1, with BALF analyzed by flow cytometry 24 h after the second challenge. (A–E) Mice aspirated 0.5 μg/Kg recombinant adiponectin alone, chitin particles alone, or particles + adiponectin. (A,F) Total CD45hi leukocytes, (B,G), neutrophils. (C,H), alveolar macrophages (D,I), eosinophils. (E,J) Quantitative RT-PCR of lung homogenate RNA to determine expression of the indicated cytokines/chemokines. N = 6–10/group. Data are a summary of 2–3 experiments. *p < 0.05, **p < 0.01, ****p < 0.0001.