Table 1.
NO and TNF-α production by RAW 264.7 macrophages activated with LPS/IFN-γ, IFN-γ, and CEA-AGE in the presence of catalase
| Activator | Inhibition of NO production (IC50 in U/mL) | Inhibition of TNF-α production (IC50 in U/mL) | % Cell viability at maximum catalase concentration |
|---|---|---|---|
| LPS/IFN-γ | 200±13 | >2000 (64±9++) | 100±11 |
| IFN-γ | 278±14 | >2000 (59±1++) | 93±6 |
| CEA-AGE | >2000 (73 ±1+) | >2000 (57±1++) | 100±6 |
+ % NO production at maximum concentration of catalase; ++ %TNF-α production at maximum concentration of catalase. Results represent the mean ± SD. NO: Nitric oxide; TNF: tumor necrosis factor; LPS: lipopolysaccharide; IFN-γ: interferon-gamma; CEA-AGE: chicken egg albumin-derived advanced glycation end product; IC50: half-maximal inhibitory concentration.