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. 2019 Aug;14(8):1462–1469. doi: 10.4103/1673-5374.253532

Figure 1.

Figure 1

SCs induced differentiation of BMSCs into neuronal-like cells.

(A, B) Characterization of SCs and BMSCs: results of flow cytometry showed that cells expressed mesenchymal stem cell markers CD90 and CD29, but not hematopoietic markers CD34 or CD45. (C) Characterization of SCs with immunostaining of S100/DAPI. (D–I) Images of time-lapse imaging: changes of BMSCs into neuronal-like cells. Arrows mark the formation of neurites and changes in cell bodies. (J) Reverse transcription-polymerase chain reaction results: expression levels of nestin and MAP2 in BMSCs cultured in unconditioned or SC-conditioned medium (mean ± SD, n = 3; one-way analysis of variance followed by Turkey’s post hoc test). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. MAP2: Microtubule-associated protein 2; SCs: Schwann cells; BMSCs: bone marrow-derived mesenchymal stem cells.