Table 4.
Genotypes and allele frequencies between TOAST subtype and controls
| SNP | Allele/genotype | Control [n(%)] | LAA (n = 281) | Cardioembolism (n = 160) | SAO (n = 210) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n(%) | Model | Chi2/STAT | OR (95% CI) | Pd | n(%) | Chi2/STAT | OR (95% CI) | Pd | n(%) | Chi2/STAT | OR (95% CI) | Pd | |||
| rs6265 | A | 709(44.8) | 243(45.8) | 149(51.0) | 175(46.1) | ||||||||||
| G | 873(55.2) | 287(54.2) | Allelica | 0.17 | 1.04 (0.86–1.27) | 0.679 | 143(49) | 3.83 | 1.28(1.00–1.65) | 0.05 | 205(53.9) | 0.19 | 1.05(0.84–1.32) | 0.664 | |
| AA | 172(21.7) | 53(20) | – | – | – | – | 31(21.2) | – | – | – | 43(22.6) | – | – | – | |
| AG | 365(46.1) | 137(51.7) | Dominantb | 0.12 | 1.02(0.70–1.50) | 0.908 | 87(59.6) | 1.64 | 2.06(0.87–4.90) | 0.102 | 89(46.8) | –0.08 | 0.98(0.63–1.53) | 0.937 | |
| GG | 254(32.1) | 75(28.3) | Recessiveb | –2.44 | 0.58(0.37–0.90) | 0.015c | 28(19.2) | –0.43 | 0.83(0.35–1.97) | 0.666 | 58(30.5) | –0.21 | 0.95(0.59–1.53) | 0.833 | |
| rs7124442 | C | 133(8.6) | 47(8.9) | 22(7.5) | 35(8.8) | ||||||||||
| T | 1415(91.4) | 479(91.1) | Allelica | 0.06 | 1.04(0.74–1.48) | 0.808 | 270(92.5) | 0.36 | 0.87(0.54–1.39) | 0.551 | 363(91.2) | 0.02 | 1.03(0.69–1.52) | 0.898 | |
| CC | 6(0.8) | 0 | – | – | – | – | 0 | – | – | – | 3(1.5) | – | – | – | |
| TC | 121(15.6) | 47(17.9) | Dominantb | 0.34 | 1.08(0.69–1.71) | 0.732 | 22(15.1) | –0.4 | 0.82(0.3–2.22) | 0.691 | 29(14.6) | –0.37 | 0.9(0.53–1.55) | 0.713 | |
| TT | 647(83.6) | 216(82.1) | Recessiveb | NA | NA | NA | 124(84.9) | NA | NA | NA | 167(83.9) | 1.26 | 3.13(0.53–18.55) | 0.209 | |
SNP: Single-nucleotide polymorphism; LAA: large-artery atherosclerosis; SAO: small artery occlusion; STAT: logistic coefficient t statistic. aChi-square test; bLogistic regression analyses adjusted on the basis of risk factors such as age, sex, hypertension, hyperlipidemia, diabetes, atrial fibrillation, smoking, and drinking; cindicates significant differences at P < 0.05; dStroke TOAST subtype cases vs. control group. Data of control group are the same as in Table 3.