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. 2019 Aug;14(8):1438–1444. doi: 10.4103/1673-5374.253527

Figure 2.

Figure 2

Electrophysiological experiments using high-frequency stimulation-induced LTP to study the effects of FGF20 in the hippocampus detected by electrophysiological recording.

(A) Representative traces from field excitatory postsynaptic potential before (gray) and after (black) the high frequency stimulation. (B) Quantitative results of LTP. Data are expressed as the mean ± SD (one-way analysis of variance followed by a Tukey post-hoc test). **P < 0.01, ***P < 0.001, vs. MPTP group. (C–E) High-frequency stimulation-induced LTP in the MPTP group, vs. the other three treatment groups. MPTP: Intraperitoneal injection of 60 mg/kg MPTP; FGF20 10 ng: intraperitoneal injection of 60 mg/kg MPTP + intraventricular injection of 10 ng FGF20; FGF20 100 ng: intraperitoneal injection of 60 mg/kg MPTP + intraventricular injection 100 ng FGF20; L-Dopa 4 mg/kg: intraperitoneal injection of 60 mg/kg MPTP + intraperitoneal injection 4 mg/kg L-Dopa. MPTP: 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; FGF20: fibroblast growth factor 20; L-Dopa: L-dihydroxyphenylalanine; LTP: long-term potentiation.