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. Author manuscript; available in PMC: 2019 Dec 4.
Published in final edited form as: Anal Chem. 2018 Nov 20;90(23):14039–14047. doi: 10.1021/acs.analchem.8b04122

Table 1.

Summary of proteomic coverages and numbers of hits observed in the STEPP-PP CsA and geldanamycin ligand binding experiments using the proteins in a yeast cell lysate.

Drug Binding Experiment Protein Assay Criteria Assayed Peptides (Proteins) Hit Peptides (Proteins) Peptides from Known Protein Target(s) Protein False Positive Rate
CsA One peptide 4265 (812) 24 (13) 11 (CPR1), 2 (CPR3) 1.4%
At least two peptides 3914 (461) 13 (2) 0%
Geldanamycin One peptide 4955 (901) 39 (33) 4 (HSP82) 3.6%
At least two peptides 4533 (492) 10 (4) 0.6%