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(a) Representation of the longest tau isoform, htau40, showing the location of the repeat domain (R1 to R4). (b) The sequence of each of the four repeats, R1, R2, R3 and R4. The two fragments known to form fibrils by themselves34, 36 and to be crucial for tau fibrillization35 are shown in black. (c) Composition of Tau3RD and Tau4RD fragments.
