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Circulating anti-mitochondrial RNA autoantibodies are detectable in sera from mice with induced SLE. Sera (1:50) from mice with induced SLE were incubated on ELISA plates coated with 200 ng murine mtRNA per well. Mice with induced SLE displayed a significant increase in serum antibodies against mtRNA in comparison to control mice. N = 4 mice per group. Data show the mean ± SD. Student's t-test. ***p < 0.001.
