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. 2019 May 10;10:1026. doi: 10.3389/fimmu.2019.01026

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Copyright © 2019 Becker, Marcoux, Allaeys, Julien, Loignon, Benk-Fortin, Rollet-Labelle, Rauch, Fortin and Boilard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibodies targeting mitochondrial RNA (AmtRNA) are elevated in SLE patients. Two different isotypes of antibodies against mtRNA, IgG (left panel) and IgM (right panel), were assessed in SLE patients and healthy individuals included in the SARD-BDB. Both AmtRNA IgG and IgM were significantly increased in SLE patients, compared to healthy individuals (p = 0.0002 and p = 0.0493, respectively). SLE: N = 86; Healthy controls: N = 30. Data show the mean ± SD. Student's t-test. ^*p < 0.05; ^***p < 0.001.